gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::G-protein View
Entry 1 of 1 :: GPR0040 ::
CLASS Galpha
FAMILY Gq/11
SUBFAMILY Galpha-14
TYPE Galpha-14

Cross References:
UniProt O95837 EMBL AF105201 | AF493903 | BC027886
InterPro IPR001019 | IPR000654 | IPR011025
PRODOM PD000281
GENEID 9630 MIM 604397
PRINTS PR00318 | PR00442 PFAM PF00503

Details:
NAME Galpha-14-Homo sapiens
DESCRIPTION Guanine nucleotide-binding protein alpha-14 subunit (G-protein alphasubunit 14).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
POST TRANSLATION MODIFICATIONS null GENE GNA14
SEQUENCE 
MAGCCCLSAEEKESQRISAEIERQLRRDKKDARRELKLLLLGTGESGKSTFIKQMRIIHG
SGYSDEDRKGFTKLVYQNIFTAMQAMIRAMDTLRIQYVCEQNKENAQIIREVEVDKVSML
SREQVEAIKQLWQDPGIQECYDRRREYQLSDSAKYYLTDIDRIATPSFVPTQQDVLRVRV
PTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFESVTSIIFLVALSEYDQVLAECDN
ENRMEESKALFKTIITYPWFLNSSVILFLNKKDLLEEKIMYSHLISYFPEYTGPKQDVRA
ARDFILKLYQDQNPDKEKVIYSHFTCATDTDNIRFVFAAVKDTILQLNLREFNLV
 FRAGMENT NO
FUNCTION Guanine nucleotide-binding proteins (G proteins) ares involved as modulators or transducers in various transmembranes signaling systems
Effectors:
1EFF0350GRK2-Homo sapiensInhibits PLC-beta activation and blocks Gqa-mediated GLUT4 translocation and glucose uptake in 3T3 adipocytes15251227 | 14654303 | 16182515
2EFF0517Phospholipase C beta-1-Homo sapiens-1Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
3EFF0521Phospholipase C beta-1-Homo sapiens-2Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
4EFF0522Phospholipase C beta-1-Homo sapiens-3Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
5EFF0530Phospholipase C beta-2-Homo sapiens-1Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
6EFF0531Phospholipase C beta-2-Homo sapiens-2Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
7EFF0541Phospholipase C beta-3-Homo sapiens-1Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
8EFF0542Phospholipase C beta-3-Homo sapiens-2Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
9EFF0556Phospholipase C beta-4-Homo sapiens-1Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
10EFF0558Phospholipase C beta-4-Homo sapiens-2Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
11EFF0560Phospholipase C beta-4-Homo sapiens-3Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615

Coupling with GPCRs:
No information



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