gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::G-protein View
Entry 1 of 1 :: GPR0225 ::
CLASS Galpha
FAMILY Gi/o
SUBFAMILY Galpha-i
TYPE Galpha-i2

Cross References:
UniProt P50147 EMBL L24549
InterPro IPR001019 | IPR001408 | IPR011025
PRODOM PD000281
GENEID 396367
PRINTS PR00318 | PR00441 PFAM PF00503

Details:
NAME Galpha-i2-Gallus gallus
DESCRIPTION Guanine nucleotide-binding protein G(i), alpha-2 subunit (Adenylatecyclase-inhibiting G alpha protein).
SPECIES Gallus gallus COMMON NAME Chicken NCBI Taxonomy 9031
POST TRANSLATION MODIFICATIONS null GENE GNAI2
SEQUENCE 
MGCTVSAEDKAAAERSRMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDG
YSEEECRQYKAVVYSNTIQSIMAIIKAMGNLQIDFGDSSRADDARQLFALACTAEEQGIM
PEDLANVIRRLWADHGVQACFNRSREYQLNDSAAYYLNDLERIARADYIPTQQDVLRTRV
KTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEE
MNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIVHSPLTICFPEYTGANKYDEA
AGYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
 FRAGMENT NO
FUNCTION Guanine nucleotide-binding proteins (G proteins) ares involved as modulators or transducers in various transmembranes signaling systems
Effectors:
1EFF0396Kir 3.1(GIRK1)-Gallus gallusStimulation15251227 | 14963032 | 11779482
2EFF0424Kir 3.4(GIRK4)-Gallus gallusStimulation15251227 | 14963032 | 11779482
3EFF0849Src tyrosine kinase-Gallus gallus-1Stimulation11007482 | 15251227 | 12209124
4EFF0850Src tyrosine kinase-Gallus gallus-2Stimulation11007482 | 15251227 | 12209124
5EFF0851Src tyrosine kinase-Gallus gallus-3Stimulation11007482 | 15251227 | 12209124
6EFF1088Tubulin-Gallus gallus-1Stimulation of GTPase activity10224115 | 15251227 | 16380086
7EFF1089Tubulin-Gallus gallus-10Stimulation of GTPase activity10224115 | 15251227 | 16380086
8EFF1090Tubulin-Gallus gallus-11Stimulation of GTPase activity10224115 | 15251227 | 16380086
9EFF1091Tubulin-Gallus gallus-12Stimulation of GTPase activity10224115 | 15251227 | 16380086
10EFF1092Tubulin-Gallus gallus-13Stimulation of GTPase activity10224115 | 15251227 | 16380086
11EFF1093Tubulin-Gallus gallus-14Stimulation of GTPase activity10224115 | 15251227 | 16380086
12EFF1094Tubulin-Gallus gallus-2Stimulation of GTPase activity10224115 | 15251227 | 16380086
13EFF1095Tubulin-Gallus gallus-3Stimulation of GTPase activity10224115 | 15251227 | 16380086
14EFF1096Tubulin-Gallus gallus-4Stimulation of GTPase activity10224115 | 15251227 | 16380086
15EFF1097Tubulin-Gallus gallus-5Stimulation of GTPase activity10224115 | 15251227 | 16380086
16EFF1098Tubulin-Gallus gallus-6Stimulation of GTPase activity10224115 | 15251227 | 16380086
17EFF1099Tubulin-Gallus gallus-7Stimulation of GTPase activity10224115 | 15251227 | 16380086
18EFF1100Tubulin-Gallus gallus-8Stimulation of GTPase activity10224115 | 15251227 | 16380086
19EFF1101Tubulin-Gallus gallus-9Stimulation of GTPase activity10224115 | 15251227 | 16380086

Coupling with GPCRs:
1GPCR0176ADENOSINE RECEPTOR_A1_Gallus gallus1662665
2GPCR0193ADENOSINE RECEPTOR_A3_Gallus gallus1323836
3GPCR0420ANGIOTENSIN RECEPTOR_AT1_Gallus gallus1310139
4GPCR0507CANNABINOID RECEPTOR_CB1_Gallus gallus2165569
5GPCR0680CHEMOKINE RECEPTOR (CX3C)_CXCR4_Gallus gallus8629022
6GPCR2731FRIZZLED_Frizzled-1_Gallus gallus11563835
7GPCR0856GLYCOPROTEIN HORMONE RECEPTOR_FSH RECEPTOR_Gallus gallus9139796
8GPCR0867GLYCOPROTEIN HORMONE RECEPTOR_LSH RECEPTOR_Gallus gallus1516719
9GPCR0130ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M2_Gallus gallus3443095
10GPCR0155ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M4_Gallus gallus3037705
11GPCR1217MELATONIN RECEPTOR_MT1_Gallus gallus-17946354
12GPCR1225MELATONIN RECEPTOR_MT1_Gallus gallus-27946354
13GPCR1228MELATONIN RECEPTOR_MT2_Gallus gallus12721330
14GPCR2799SMOOTHENED_smoothened_Gallus gallus10835429
15GPCR1247NEUROPEPTIDE Y RECEPTOR_Y1_Gallus gallus-11321422
16GPCR1248NEUROPEPTIDE Y RECEPTOR_Y1_Gallus gallus-21321422



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