gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR1228 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY MELATONIN RECEPTOR
SUBFAMILY MT2

Cross References:
UniProt P51050 EMBL U30609
InterPro IPR000276 | IPR002278 | IPR000025 GPCRDB mtr1b_chick
PRINTS PR00237 | PR01149 | PR00857 PFAM PF00001

Details:
NAME MELATONIN RECEPTOR_MT2_Gallus gallus
DESCRIPTION Melatonin receptor type 1B .
SPECIES Gallus gallus COMMON NAME Chicken NCBI Taxonomy 9031
GENE -
SEQUENCE
GNAFVVSLALADLVVALYPYPLVLLAIFHNGWTLGEMHCKVSGFVMGLSVIGSIFNITAI
AINRYCYICHSFAYDKVYSCWNTMLYVSLIWVLTVIATVPNFFVGSLKYDPRIYSCTFVQ
TASSYYTIAVVVIHFIVPITVVSFCYLRIWVLVLQVRRRVKSETKPRLKPSDFRNFLTMF
VVFVIFAFCWAPLNFIGLAVAINPSEMAPKVPEWLFIISYFMAYFNSCLNAIIYGLLNQN
FRNEYKRILMSLWMPRLFFQDTSKGGTDGQKSKPSPALNNNDQMKTDTL
FRAGMENT YES

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11940583
HETERODIMER INFORMATION Forms heterodimers with Melatonin MT1 Receptors. METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11940583

Coupling with G-proteins:
Family:Gi/o REFERENCES:12721330
1GPR0217Galpha-i1-Gallus gallus
2GPR0225Galpha-i2-Gallus gallus


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
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Laboratory