G-protein coupled receptors form the largest and most diverse superfamily of transmembrane receptors in eykaryotic cells. All known GPCRs share common topology, which consists of 7 transmembrane -helices and extracellular N-terminals. Even though GPCRs share common architecture and function, they show important diversity at sequence level, and, therefore are divided into families (Fredriksson, et al., 2003; Kristiansen, 2004). This lack of sequence similarity makes difficult the detection of GPCRs in proteomes, especially, the finding of novel members of the GPCR superfamily. In this work, we developed a pipeline for the accurate detection of GPCRs in proteomes called GPCRpipe.

University of Athens
Faculty of Biology
Biophysics & Bioinformatics Laboratory