The cutoff score for the RR-1 and RR-2 profiles is now zero, in order to catch all probable CPRs.

If the protein only matches with one of the two profiles we suggest that it belongs in the respective family.

If the protein matches with both profiles we suggest that the protein belongs in the family against which it has a higher score (as described in the manuscript and the manual).

If you want a more stringent cutoff choose: 35.00 for RR-1!!!

If you want a more stringent cutoff choose: 37.50 for RR-2!!!

****NEW (Added on May 2023):

When proteins have been assigned to either the CPAP1 or CPAP3 families by our tool, it is essential that the sequence be checked to be sure they have no more than 1 or 3 CBM_14 domains, respectively. This can be done quickly by using NCBI Conserved Domain Search [ https://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi].