gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0761 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY DOPAMINE RECEPTOR
SUBFAMILY D1

Cross References:
UniProt Q61616 | Q8C8P8 EMBL AK044723 | L20336
InterPro IPR015694 | IPR001413 | IPR000929 | IPR000276 GPCRDB drd1_mouse
GENEID 13488
PRINTS PR00565 | PR00242 | PR00237 PFAM PF00001

Details:
NAME DOPAMINE RECEPTOR_D1_Mus musculus-1
DESCRIPTION D(1A) dopamine receptor.
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Drd1 | Drd1a | Gpcr15
SEQUENCE
MAPNTSTMDETGLPVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNF
FVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDR
YWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLED
AEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKN
CQTTTGNGNPVECSQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGS
EETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIET
VSINNNGAVMFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKREEAGGIPKPLEKLSPAL
SVILDYDTDVSLEKIQPVTHSGQHST
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 9804783
HETERODIMER INFORMATION Forms heterodimers with Adenosine A1 Receptor. Heterodimerization results in altered D1 receptor signalling METHOD Immunoprecipitation REFERENCES 10890919

Coupling with G-proteins:
Family:Gs REFERENCES:11238742
1GPR0104Galpha-olf-Mus musculus
2GPR0123Galpha-s-Mus musculus-2
3GPR0391Galpha-s-Mus musculus


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory