gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0709 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY CHEMOTACTIC PEPTIDE RECEPTOR
SUBFAMILY C5A

Cross References:
UniProt P21730 EMBL X57250 | X58674 | M62505 | AY221091 | BT007358 | BC008982 | S56556 | S56557
InterPro IPR002234 | IPR001274 | IPR000276 GPCRDB c5ar_human
GENEID 728 MIM 113995
PRINTS PR01104 | PR00426 | PR00237 PFAM PF00001

Details:
NAME CHEMOTACTIC PEPTIDE RECEPTOR_C5A_Homo sapiens-2
DESCRIPTION C5a anaphylatoxin chemotactic receptor (C5a-R) (C5aR) (CD88 antigen).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE C5AR1 | C5AR | C5R1
SEQUENCE 
MNSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVW
VTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNM
YASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREE
YFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKT
LKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLNKLDSLCVSFAYINCCINPIIY
VVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
 FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12835318

Coupling with G-proteins:
Family:Gq/11 REFERENCES:7870028
1GPR0043Galpha-16-Homo sapiens
Family:Gi/o REFERENCES:7887933
2GPR0020Galpha-o1-Homo sapiens
3GPR0109Galpha-i3-Homo sapiens
4GPR0218Galpha-i1-Homo sapiens-1
5GPR0226Galpha-i2-Homo sapiens-2
6GPR0261Galpha-i1-Homo sapiens-2
7GPR0334Galpha-o-Homo sapiens
8GPR0365Galpha-i2-Homo sapiens-1
9GPR0128Galpha-z-Homo sapiens-2
10GPR0327Galpha-z-Homo sapiens-3
11GPR0333Galpha-z-Homo sapiens-1

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athina University of Athens
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 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory