gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0650 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY CHEMOKINE RECEPTOR (CX3C)
SUBFAMILY CXCR4

Cross References:
UniProt Q8UUW8 EMBL AY057095
InterPro IPR000355 | IPR001277 | IPR000276 | IPR003006 GPCRDB q8uuw8_danre
PRINTS PR00657 | PR00645 | PR00237 PFAM PF00001

Details:
NAME CHEMOKINE RECEPTOR (CX3C)_CXCR4_Brachydanio rerio -1
DESCRIPTION Cxcr4A.
SPECIES Danio rerio COMMON NAME Zebrafish NCBI Taxonomy 7955
GENE cxcr4a
SEQUENCE
MAYYEHIVFEDDLSADNSSEFGSGDIGANFEVPCDVEVSHDFQRIFLPTVYGIIFVLGLI
GNGLVVLVMGCQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDAAKDWYFGGFMCVAVHM
IYTVNLYSSVLILAFISLDRYLAVVRATNSQGPRKLLANRIIYVGVWLPAALLTVPDLVF
AKAESSAIRTFCERIYPQDSFVTWVVAFRFQHILVGFVLPGLVILICYCIIISKLSRGSK
GTQKRKALKTTVVLIVCFFVCWLPYCGGILLDTLMMLEVIPHSCELEQGLQKWIFVTEAL
AYFHCCLNPILYAFLGVKFKKSARSALSPSRGSSLKFLSKKRTGMSSVSTESESSSFHSS
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12433920 | 12089144

Coupling with G-proteins:
Family:Gi/o REFERENCES:8629022
1GPR0005Galpha-i2-Danio rerio-2
2GPR0298Galpha-i2-Danio rerio-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory