gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::Effector View
Entry 1 of 1 :: EFF0094 ::
FAMILY Ion channels
SUBFAMILY ATP-sensitive inward rectifier potassium channels
TYPE ATP-sensitive inward rectifier potassium channel 12

Cross References:
UniProt P52188 EMBL X78461
InterPro IPR001838 | IPR003272 | IPR013521 | IPR013518 | IPR013673
PRODOM PD001103
PRINTS PR01325 | PR01320 PFAM PF01007 | PF08466

Details:
NAME ATP-sensitive inward rectifier potassium channel-12-Rattus norvegicus
DESCRIPTION ATP-sensitive inward rectifier potassium channel 12 (Potassiumchannel, inwardly rectifying subfamily J member 12) (Inward rectifierK(+) channel Kir2.2) (IRK2).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Kcnj12 | Irk2
SEQUENCE 
MTAASRANPYSIVSSEEDGLHLVTMSGANGFGNGKVHTRRRCRNRFVKKNGQCNIEFANM
DEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHGDLEPAEGRGR
TPCVLQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVGCIIDSFMIGAI
MAKMGRPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEE
GEYIPLDQIDIDVGF
 FRAGMENT NO
FUNCTION Probably participates in establishing action potentials waveform and excitability of neuronal and muscle tissues
Interacting with G-proteins:
Family:Gbeta REFERENCES:15251227 | 10990455
1GPR0149Gbeta-1-Rattus norvegicus-2
2GPR0157Gbeta-2-Rattus norvegicus-2
3GPR0162Gbeta-3-Rattus norvegicus
4GPR0166Gbeta-4-Rattus norvegicus
5GPR0169Gbeta-5-Rattus norvegicus
6GPR0396Gbeta-2-Rattus norvegicus-1
7GPR0397Gbeta-1-Rattus norvegicus-1
Family:Ggamma REFERENCES:15251227 | 10990455
8GPR0190Ggamma-5-Rattus norvegicus
9GPR0194Ggamma-7-Rattus norvegicus
10GPR0197Ggamma-8-Rattus norvegicus
11GPR0201Ggamma-11-Rattus norvegicus
12GPR0256Ggamma-2-Rattus norvegicus
13GPR0257Ggamma-3-Rattus norvegicus
14GPR0258Ggamma-4-Rattus norvegicus
15GPR0259Ggamma-10-Rattus norvegicus
16GPR0260Ggamma-12-Rattus norvegicus

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athina University of Athens
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 Dept. of Cell Biology and Biophysics
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