gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::Effector View
Entry 1 of 1 :: EFF0584 ::
FAMILY PI3/PI4 kinases
SUBFAMILY Class Ia PI3Ks
TYPE PI3K beta

Cross References:
UniProt Q9Z1L0 EMBL AJ012482
InterPro IPR000403 | IPR002420 | IPR003113 | IPR000341 | IPR001263 | IPR015433
GENEID 85243
PFAM PF00454 | PF00792 | PF02192 | PF00794 | PF00613

Details:
NAME PI3K beta-Rattus norvegicus
DESCRIPTION Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit betaisoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinasep110) (PI3K) (PI3Kbeta).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Pik3cb
SEQUENCE
MCFRSIMPPAMADTLDIWAVDSQIASDGSISVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPAE
KLDSKIGVLIGKGLHEFDALKDPEVNEFRRKMRKFSEDKIQSLVGLSWIDWLKHTYPPEH
EPSVLENLEDKLYGGKLVVAVHFENSQDVFSFQVSPNLNPIKINELAIQKRLTIRGKEEE
ASPCDYVLQVSGRVE
FRAGMENT NO
FUNCTION Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with as preference for PtdIns(4,5)P2 (By similarity)
Interacting with G-proteins:
Family:Gq/11 REFERENCES:16182515
1GPR0242Galpha-q-Rattus norvegicus
Family:Gbeta REFERENCES:9305878 | 12502714
2GPR0149Gbeta-1-Rattus norvegicus-2
3GPR0157Gbeta-2-Rattus norvegicus-2
4GPR0162Gbeta-3-Rattus norvegicus
5GPR0166Gbeta-4-Rattus norvegicus
6GPR0169Gbeta-5-Rattus norvegicus
7GPR0396Gbeta-2-Rattus norvegicus-1
8GPR0397Gbeta-1-Rattus norvegicus-1
Family:Ggamma REFERENCES:9305878 | 12502714
9GPR0190Ggamma-5-Rattus norvegicus
10GPR0194Ggamma-7-Rattus norvegicus
11GPR0197Ggamma-8-Rattus norvegicus
12GPR0201Ggamma-11-Rattus norvegicus
13GPR0256Ggamma-2-Rattus norvegicus
14GPR0257Ggamma-3-Rattus norvegicus
15GPR0258Ggamma-4-Rattus norvegicus
16GPR0259Ggamma-10-Rattus norvegicus
17GPR0260Ggamma-12-Rattus norvegicus


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