gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::Effector View
Entry 1 of 1 :: EFF0488 ::
FAMILY Phosphodiesterases
SUBFAMILY Rhodopsin-sensitive cGMP-specific PDEases
TYPE Phosphodiesterase 6

Cross References:
UniProt P16499 EMBL M26061
InterPro IPR003018 | IPR003607 | IPR002073
GENEID 5145 MIM 180071 | 268000
PRINTS PR00387 PFAM PF01590 | PF00233

Details:
NAME Phosphodiesterase-6-Homo sapiens-3
DESCRIPTION Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE PDE6A | PDEA
SEQUENCE 
MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAKEAAVDFSNYHSPSSMEESEI
IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAV
LEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILAS
PIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKWYHLSYLHNCETRRGQI
LLWSGSKVFEELTDI
 FRAGMENT NO
FUNCTION This protein participates in processes of transmissions and amplification of the visual signal
Interacting with G-proteins:
Family:Gi/o REFERENCES:15251227 | 15988071 | 14699118
1GPR0247Galpha-t1-Homo sapiens
2GPR0250Galpha-t2-Homo sapiens
3GPR0279Galpha-t-Homo sapiens

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athina University of Athens
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