Photo Dr. Nikos Papandreou

2005 Defended PhD thesis

1997 - 2005: PhD student in the Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens.
Title: "Contribution in the study of substrate selectivity of the enzyme Dihydrofolate Reductase (DHFR). Structural and biochemical studies of novel inhibitors of the enzyme and their complexes."
Supervisor: Professor Stavros J. Hamodrakas

1992 - 1997:Undergraduate studies in the Faculty of Biology, University of Athens.
Diploma Thesis: "Structural studies of the plant lectin Concanavalin A (Con A)."
Supervisor: Professor Stavros J. Hamodrakas

My research interests are oriented towards the determination of structural features of proteins and small organic compounds by X-Ray crystallographic methods. At present my research is focused on structural studies of the enzyme Dihydrofolate Reductase.
I am also interested in the determination of protein structures by comparative modeling, in cases where no experimental data can be obtained.


Giannopoulou, A.D., Velentzas, A.D., Konstantakou, E.G., Avgeris, M., Katarachia, S.A., Papandreou, N.C., Kalavros, N.I., Mpakou, V.E.,Iconomidou, V., Anastasiadou, E., Kostakis, I.K., Papassideri, I.S., Voutsinas, G.E., Scorilas, A., Stravopodis, D.J. (2019) Revisiting Histone Deacetylases in Human Tumorigenesis: The Paradigm of Urothelial Bladder Cancer. Int. J. Mol. Sci. 20(6):E1291. doi:10.3390/ijms20061291 [Abstract]

Valassakis, C., Dervisi, I., Agalou, A., Papandreou,N., Kapetsis, G., Podia, V., Haralampidis, K., Iconomidou, V.A., Spaink, H.P., Roussis, A. (2019) Novel interactions of Selenium Binding Protein family with the PICOT containing proteins AtGRXS14 and AtGRXS16 in Arabidopsis thaliana. Plant Sci. Apr;281:102-112. doi:10.1016/j.plantsci.2019.01.021 [Abstract]

Giannopoulou, A.D., Konstantakou, E.G., Velentzas, A.D., Avgeris, S.N., Avgeris, M., Papandreou, N.C., Zoi, I., Filippa, V., Katarachia, S., Lampidonis, A.D., Prompona, A., Syntichaki, P., Piperi, P., Basdra, E.K., Iconomidou, V., Papadavid, E., Anastasiadou, E., Papassideri, I.S., Papavassiliou, A.G., Voutsinas, G.E., Scorilas, A., Stravopodis, D.J. (2019) Gene-Specific Intron Retention Serves as Molecular Signature that Distinguishes Melanoma from Non-Melanoma Cancer Cells in Greek Patients. Int. J. Mol. Sci. 20(4):E937. doi:10.3390/ijms20040937 [Abstract]

Nastou, K.C., Tsaousis, G.N., Papandreou, N.C., Hamodrakas, S.J. (2016) MBPpred: Proteome-wide detection of membrane lipid-binding proteins using profile Hidden Markov Models. Biochim. Biophys. Acta Volume 1864, Issue 7, pp. 747–754. [Abstract] doi: 10.1016/j.bbapap.2016.03.015.

Rerra, A.I.G., Grimanelli, V.P., Papandreou, N.C., Hamodrakas, S.J. (2016) Optimizing the Aggregation Propensity of Therapeutic Monoclonal Antibodies against Cancer and Autoimmune Diseases: A Computational Study. Int. J. Biochem. Res. Rev. 10(1): 1-15, 2016, Article no.IJBcRR.23216.  doi: 10.9734/IJBCRR/2016/23216 [Abstract]

Papadimitriou, K., Anastasiou, R., Maistrou, E., Plakas, T., Papandreou, N.C., Hamodrakas, S.J., Ferreira, S., Supply, P., Renault, P., Pot, B., Tsakalidou, E. (2015) Acquisition through horizontal gene transfer of plasmid pSMA198 by Streptococcus macedonicus ACA-DC 198 points towards the dairy origin of the species.PLoS One. 2015 Jan 13;10(1):e0116337. doi: 10.1371/journal.pone.0116337 [Abstract]

Ioannidou, Z.S., Theodoropoulou, M.C., Papandreou, N.C., Willis, J.H., Hamodrakas, S.J. (2014) CutProtFam-Pred: Detection and classification of putative structural cuticular proteins from sequence alone, based on profile Hidden Markov Models. Insect. Biochem. Mol. Biol., Volume 52, September 2014, Pages 51-59. doi: 10.1016/j.ibmb.2014.06.004 [Abstract]

Papadimitriou, K., Anastasiou, R., Mavrogonatou, E., Blom, J., Papandreou, N.C., Hamodrakas, S.J., Ferreira, S., Renault, P., Supply, P., Pot, B., Tsakalidou, E. (2014) Comparative genomics of the dairy isolate Streptococcus macedonicus ACA-DC 198 against related members of the Streptococcus bovis/Streptococcus equinus complex. BMC Genomics, 15:272. doi: 10.1186/1471-2164-15-272 [Abstract]

Giannopoulos, N.G., Michalopoulos, I., Papandreou, N.C., Malatras, A., Iconomidou, V.A., Hamodrakas, S.J. (2013) LepChorionDB, a database of Lepidopteran chorion proteins and a set of tools useful for the identification of chorion proteins in Lepidopteran proteomes. Insect Biochem Mol Biol. , 43: 189-196. [Abstract]

Tsolis, A.C., Papandreou, N.C., Iconomidou, V.A., Hamodrakas, S.J. (2013) A Consensus Method for the Prediction of "Aggregation-Prone" Peptides in Globular Proteins. PLoS ONE, 8(1): e54175. [Abstract]

Willis, J.H., Papandreou, N.C., Iconomidou, V.A., Hamodrakas, S.J. (2012) Cuticular proteins. Chapter 5 in Insect Molecular Biology and Biochemistry (ed. L. I. Gilbert) Academic Press pp. 134-166.

Papadimitriou K., S. Ferreira, N.C. Papandreou, E. Mavrogonatou, P. Supply, B. Pot and E. Tsakalidou (2012) Complete genome sequence of the dairy isolate Streptococcus macedonicus ACA-DC 198. Journal of Bacteriology, 194: 1838-1839.[Abstract]

Satagopam, V.P., Theodoropoulou, M.C., Stampolakis, C.K., Pavlopoulos, G.A., Papandreou, N.C., Bagos, P.G., Schneider, R., Hamodrakas, S.J. (2010) GPCRs, G-proteins, Effectors and their interactions: Human-gpDB, a database employing advanced visualization tools and data integration techniques. Database (Oxford), 2010. [Abstract]

Papandreou, N.C., Iconomidou, V.A., Willis, J.H., Hamodrakas, S.J.(2010) A possible structural model of members of the CPF family of cuticular proteins implicating binding to components other than chitin. J Insect Physiol., 56(10): 1420-1426.[Abstract]

Kastritis, P.L., Papandreou, N.C., Hamodrakas, S.J. (2007) Haloadaptation: Insights from comparative modeling studies of halophilic archaeal DHFRs. Int. J.Biol. Macromol. 41(4): 447-53. [Abstract]

Papandreou N.C., Makedonopoulou S., Antoniadou-Vyza E.A., Mavridis I.M., Hamodrakas S.J. (2002) 2,4-Diamino-5-(1-naphthyl)-3,5-diaza-1-azoniaspiro[5.5]undeca-1,3-diene chloride. Acta Crystallogr C. , 58, 730-732. [Abstract]