gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::G-protein View
Entry 1 of 1 :: GPR0125 ::
CLASS Galpha
FAMILY Gs
SUBFAMILY Galpha-s
TYPE Galpha-s

Cross References:
UniProt P29797 EMBL X63893
InterPro IPR001019 | IPR000367 | IPR011025
PRODOM PD000281
GENEID 397580
PRINTS PR00318 | PR00443 PFAM PF00503

Details:
NAME Galpha-s-Sus scrofa
DESCRIPTION Guanine nucleotide-binding protein G(s) subunit alpha (Adenylatecyclase-stimulating G alpha protein).
SPECIES Sus scrofa COMMON NAME Pig NCBI Taxonomy 9823
POST TRANSLATION MODIFICATIONS null GENE GNAS
SEQUENCE 
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQM
RILHVNGFNGDEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVM
NVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQDDYVPSDQ
DLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNM
VIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIELFVLDD
RLFQERPFSFIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRH
YCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
 FRAGMENT NO
FUNCTION Guanine nucleotide-binding proteins (G proteins) ares involved as modulators or transducers in various transmembranes signaling systems
Effectors:
1EFF0037Adenylate cyclase-5-Sus scrofaStimulation15251227 | 15922020 | 14993377 | 11376933
2EFF1366Tubulin-Sus scrofa-1Stimulation of GTPase activity10224115 | 15251227 | 16380086
3EFF1367Tubulin-Sus scrofa-2Stimulation of GTPase activity10224115 | 15251227 | 16380086
4EFF1368Tubulin-Sus scrofa-3Stimulation of GTPase activity10224115 | 15251227 | 16380086
5EFF1369Tubulin-Sus scrofa-4Stimulation of GTPase activity10224115 | 15251227 | 16380086

Coupling with GPCRs:
1GPCR01115-HYDROXYTRYPTAMINE RECEPTOR_5-HT-7_Sus scrofa8397408
2GPCR0237ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2A(Adrenoceptor)_Sus scrofa8662784
3GPCR0316ADRENOCEPTOR (B-ADRENOCEPTOR)_B1(Adrenoceptor)_Sus scrofa2825170
4GPCR0327ADRENOCEPTOR (B-ADRENOCEPTOR)_B2(Adrenoceptor)_Sus scrofa-23041227
5GPCR0359ADRENOCEPTOR (B-ADRENOCEPTOR)_B2(Adrenoceptor)_Sus scrofa-13041227
6GPCR0398ADRENOCEPTOR (B-ADRENOCEPTOR)_B3(Adrenoceptor)_Sus scrofa-12570461
7GPCR2576CALCITONIN, AMYLIN, CGRP, AND ADRENOMEDULIN RECEPTOR_CALCITONIN_Sus scrofa1331173
8GPCR0746DOPAMINE RECEPTOR_D1_Sus scrofa2144334
9GPCR2428PROSTANOID RECEPTOR_EP3_Sus scrofa11095474
10GPCR0813ENDOTHELIN RECEPTOR_ET-A_Sus scrofa1849646
11GPCR0842GLYCOPROTEIN HORMONE RECEPTOR_FSH RECEPTOR_Sus scrofa9139796
12GPCR0872GLYCOPROTEIN HORMONE RECEPTOR_LSH RECEPTOR_Sus scrofa1516719
13GPCR1153MELANOCORTIN RECEPTOR_MC1_Sus scrofa-11516719
14GPCR1157MELANOCORTIN RECEPTOR_MC1_Sus scrofa-21516719
15GPCR1191MELANOCORTIN RECEPTOR_MC3_Sus scrofa8463333
16GPCR1200MELANOCORTIN RECEPTOR_MC4_Sus scrofa8392067
17GPCR1203MELANOCORTIN RECEPTOR_MC5_Sus scrofa8185570
18GPCR2613PARATHYROID HORMONE RECEPTOR_PARATHYROID HORMONE/PARATHYROID HORMONE-RELATED PEPTIDE RECEPTOR_Sus scrofa1658941
19GPCR0884GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Sus scrofa-28552586
20GPCR2570VASOPRESSIN AND OXYTOCIN RECEPTOR_V2_Sus scrofa1534150
21GPCR2625VASOACTIVE INTESTINAL PEPTIDE AND PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE RECEPTOR_VPAC1_Sus scrofa-21675791
22GPCR2629VASOACTIVE INTESTINAL PEPTIDE AND PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE RECEPTOR_VPAC1_Sus scrofa-11675791



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