gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0882 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY GLYCOPROTEIN HORMONE RECEPTOR
SUBFAMILY TSH RECEPTOR

Cross References:
UniProt P56495 EMBL Y13434
InterPro IPR000276 | IPR002131 | IPR002274 GPCRDB tshr_sheep
GENEID 443428
PRINTS PR00373 | PR00237 | PR01145 PFAM PF00001

Details:
NAME GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Ovis aries
DESCRIPTION Thyrotropin receptor precursor (TSH-R) (Thyroid-stimulating hormonereceptor).
SPECIES Ovis aries COMMON NAME Sheep NCBI Taxonomy 9940
GENE TSHR
SEQUENCE
MRPTPLLRLALLLVLPSSLWGERCPSPPCECRQEDDFRVTCKDIQRIPSLPPSTQTLKFI
ETHLKTIPSRAFSNLPNISRIYLSIDATLQQLESHSFYNLSKVTHIEIRNTRSLTYIDSG
ALKELPLLKFLGIFNTGLRVFPDLTKIYSTDVFFILEITDNPYMTSVPANAFQGLSNETL
TLKLYNNGFTSIQGHAFNGTKLDAVYLNKNKYLTVIDQDAFAGVYSGPTLLDISYTSVTA
LPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKNIRGILQSLM
CNESSIWGLRQRKSASALNGPFYQEYEEDLGDGSAGYKENSKFQDTHSNSHYYVFFEDQE
DEIIGFGQELKNPQEETLQAFDNHYDYTVCGGSEEMVCTPKSDEFNPCEDIMGYKFLRIV
VWFVSLLALLGNVFVLVILLTSHYKLTVPRFLMCNLAFADFCMGLYLLLIASVDLYTQSE
YYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMHLDRKIRLWHAYV
IMLGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIILVLLLNIIAFIIVCAC
YVKIYITVRNPHYNPGDKDTRIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSK
ILLVLFYPLNSCANPFLYAIFTKAFQRDVFMLLSKFGICKRQAQAYRGQRVSSKNSTGIR
VQKVPPDVRQSLPNVQDDYELLGNSHLTPKQQDQTSKEYKQTVL
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12223484

Coupling with G-proteins:
No information


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory