gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0865 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY GLYCOPROTEIN HORMONE RECEPTOR
SUBFAMILY LSH RECEPTOR

Cross References:
UniProt P16235 | P70646 | Q63807 | Q63808 | Q63809 | Q6LDI7 EMBL M26199 | M61212 | M61211 | S40803 | S40787 | S40903 | S40904 | S40905 | S40907 | S40909 | S40918 | S40920 | S40795 | S40798 | S40795 | S40787 | S40903 | S40904 | S40905 | S40907 | S40909 | S40918 | S40920 | S40803 | S40787 | S40903 | S40907 | S40909 | S40918 | S40920 | S40795 | S40798 | S40803 | S40787 | S40903 | S40904 | S40905 | S40907 | S40909 | S40918 | S40920 | S40795 | S40798 | S40803 | S40787 | S40903 | S40904 | S40905 | S40909 | S40918 | S40920 | S40795 | S40798 | M68928 | M68917 | M68918 | M68919 | M68920 | M68921 | M68922 | M68923 | M68925 | M68926 | M68927 | M63926 | M63918 | M63919 | M63920 | M63921 | M63922 | M63923 | M63924 | M63925
InterPro IPR000276 | IPR002131 | IPR000372 | IPR002273 GPCRDB lshr_rat
GENEID 25477
PRINTS PR00373 | PR00237 | PR01144 PFAM PF00001

Details:
NAME GLYCOPROTEIN HORMONE RECEPTOR_LSH RECEPTOR_Rattus norvegicus
DESCRIPTION Lutropin-choriogonadotropic hormone receptor precursor (LH/CG-R) (LSH-R) (Luteinizing hormone receptor).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Lhcgr
SEQUENCE
MGRRVPALRQLLVLAVLLLKPSQLQSRELSGSRCPEPCDCAPDGALRCPGPRAGLARLSL
TYLPVKVIPSQAFRGLNEVVKIEISQSDSLERIEANAFDNLLNLSELLIQNTKNLLYIEP
GAFTNLPRLKYLSICNTGIRTLPDVTKISSSEFNFILEICDNLHITTIPGNAFQGMNNES
VTLKLYGNGFEEVQSHAFNGTTLISLELKENIYLEKMHSGAFQGATGPSILDISSTKLQA
LPSHGLESIQTLIALSSYSLKTLPSKEKFTSLLVATLTYPSHCCAFRNLPKKEQNFSFSI
FENFSKQCESTVRKADNETLYSAIFEENELSGWDYDYGFCSPKTLQCAPEPDAFNPCEDI
MGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIA
SVDSQTKGQYYNHAIDWQTGSGCGAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQ
KLRLRHAIPIMLGGWLFSTLIATMPLVGISNYMKVSICLPMDVESTLSQVYILSILILNV
VAFVVICACYIRIYFAVQNPELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKV
PLITVTNSKILLVLFYPVNSCANPFLYAIFTKAFQRDFLLLLSRFGCCKRRAELYRRKEF
SAYTSNCKNGFPGASKPSQATLKLSTVHCQQPIPPRALTH
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Photobleaching Fluorescence Resonance Energy Transfer (FRET) REFERENCES 11108263

Scaffold:
TYPE GIPC( GAIP-interacting protein) REFERENCES 14507927
TYPE NHERF1( Na+/H+ exchange regulatory factor) /EBP50( ezrin-radixin-moesin binding phosphoprotein 50-kD protein) REFERENCES 14507927
TYPE p38JAB1 REFERENCES 10788448

Coupling with G-proteins:
Family:Gi/o REFERENCES:1516719
1GPR0026Galpha-o-Rattus norvegicus
2GPR0111Galpha-i3-Rattus norvegicus
3GPR0221Galpha-i1-Rattus norvegicus
4GPR0229Galpha-i2-Rattus norvegicus
Family:Gq/11 REFERENCES:1516719
5GPR0032Galpha-11-Rattus norvegicus
6GPR0242Galpha-q-Rattus norvegicus
Family:Gs REFERENCES:1516719
7GPR0124Galpha-s-Rattus norvegicus-2
8GPR0392Galpha-s-Rattus norvegicus-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory