gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0081 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY 5-HYDROXYTRYPTAMINE RECEPTOR
SUBFAMILY 5-HT-2B

Cross References:
UniProt P30994 | Q9QW44 EMBL X66842
InterPro IPR000482 | IPR002231 | IPR000276 GPCRDB 5ht2b_rat
GENEID 29581
PRINTS PR00651 | PR01101 | PR00237 PFAM PF00001

Details:
NAME 5-HYDROXYTRYPTAMINE RECEPTOR_5-HT-2B_Rattus norvegicus
DESCRIPTION 5-hydroxytryptamine receptor 2B (5-HT-2B) (Serotonin receptor 2B) (5-HT-2F) (Stomach fundus serotonin receptor).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Htr2b | Srl
SEQUENCE
MASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLI
FAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATW
PLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWL
ISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTI
HALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETL
MRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTL
LQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSM
VENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
FRAGMENT NO

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Scaffold:
TYPE MUPP1( multiple activated protein kinase 1) REFERENCES 11150294
TYPE nNOS( neuronal nitric oxide synthase) NOS1 REFERENCES 10734074

Coupling with G-proteins:
Family:Gq/11 REFERENCES:8786115
1GPR0032Galpha-11-Rattus norvegicus
2GPR0242Galpha-q-Rattus norvegicus


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory