gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0795 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY DOPAMINE RECEPTOR
SUBFAMILY D3

Cross References:
UniProt P52703 EMBL U21307
InterPro IPR001620 | IPR000929 | IPR000276 GPCRDB drd3_cerae
PRINTS PR00568 | PR00242 | PR00237 PFAM PF00001

Details:
NAME DOPAMINE RECEPTOR_D3_Cercopithecus aethiops
DESCRIPTION D(3) dopamine receptor.
SPECIES Cercopithecus aethiops COMMON NAME Green monkey NCBI Taxonomy 9534
GENE DRD3
SEQUENCE
MAPLSQLSGHLNYTCGVENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRVCCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVTLMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDRAHLELKRYYSICQDTALGGPGFQERGGELKREERTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 9361002 | 10999936 | 11039730
HETERODIMER INFORMATION Forms heterodimers with Dopamine D2 Receptors. Dimerization results in an Increased affnity and potency for agonists and antagonists METHOD Functional reconstitution REFERENCES 11373283

Scaffold:
TYPE alpha-filamin/ABP280( actin binding protein 280) REFERENCES 11911837 | 1239393
TYPE Nck, Grb2 REFERENCES 9843378 | 11384839

Coupling with G-proteins:
No information


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory