gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0779 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY DOPAMINE RECEPTOR
SUBFAMILY D2

Cross References:
UniProt P52702 EMBL U18547
InterPro IPR001922 | IPR000929 | IPR000276 GPCRDB drd2_cerae
PRINTS PR00567 | PR00242 | PR00237 PFAM PF00001

Details:
NAME DOPAMINE RECEPTOR_D2_Cercopithecus aethiops
DESCRIPTION D(2) dopamine receptor (Dopamine D2 receptor).
SPECIES Cercopithecus aethiops COMMON NAME Green monkey NCBI Taxonomy 9534
GENE DRD2
SEQUENCE 
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSKIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRSHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKNHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC
 FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 11682068
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10860933
HETERODIMER INFORMATION Forms heterodimers with Dopamine D3 Receptors. Dimerization results in an Increased affnity and potency for agonists and antagonists METHOD Functional reconstitution REFERENCES 11373283
HETERODIMER INFORMATION Forms heterodimer with Somatostatin SST5 Receptor. Dimerization results in increased ligand binding affnity and enhanced signalling METHOD Photobleaching Fluorescence Resonance Energy Transfer (FRET) REFERENCES 10753124
HETERODIMER INFORMATION Forms heterodimers with Adenosine A2A Receptor. Heterodimerization results in co-desensitization and co-internalization of the receptors METHOD Immunoprecipitation REFERENCES 11872740

Scaffold:
TYPE alpha-filamin/ABP280( actin binding protein 280) REFERENCES 11911837 | 1239393
TYPE Protein 4.1N REFERENCES 12181426
TYPE Spinophilin/neurabin II REFERENCES 10391935

Coupling with G-proteins:
No information

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athina University of Athens
 Faculty of Biology
 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory