gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0757 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY DOPAMINE RECEPTOR
SUBFAMILY D1

Cross References:
UniProt O77680 EMBL AF077862
InterPro IPR015694 | IPR001413 | IPR000929 | IPR000276 GPCRDB drd1_macmu
PRINTS PR00565 | PR00242 | PR00237 PFAM PF00001

Details:
NAME DOPAMINE RECEPTOR_D1_Macaca mulatta
DESCRIPTION D(1A) dopamine receptor.
SPECIES Macaca mulatta COMMON NAME Rhesus macaque NCBI Taxonomy 9544
GENE DRD1
SEQUENCE
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
GETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 9804783
HETERODIMER INFORMATION Forms heterodimers with Adenosine A1 Receptor. Heterodimerization results in altered D1 receptor signalling METHOD Immunoprecipitation REFERENCES 10890919

Coupling with G-proteins:
No information


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory