gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0573 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY CHEMOKINE RECEPTOR (CC)
SUBFAMILY CCR5

Cross References:
UniProt P56493 EMBL U83324 | U83325 | AB015944
InterPro IPR002240 | IPR000355 | IPR000276 GPCRDB ccr5_cerae
PRINTS PR00657 | PR01110 | PR00237 PFAM PF00001

Details:
NAME CHEMOKINE RECEPTOR (CC)_CCR5_Cercopithecus aethiops
DESCRIPTION C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5)(CD195 antigen).
SPECIES Cercopithecus aethiops COMMON NAME Green monkey NCBI Taxonomy 9534
GENE CCR5 | CMKBR5
SEQUENCE
MDYQVSSPTYDIDNYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKR
LKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAIVHAVFALKARTVTFGVVTSVITWVVAVFASLPRIIFTRSQREGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQETSVGF
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12089144
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10725362
HETERODIMER INFORMATION Forms heterodimers with Chemokine CCR2 Receptor. Dimerization increases the sensitivity and range of signalling pathways activated METHOD Immunoprecipitation, Fluorescence Resonance Energy Transfer (FRET) REFERENCES 11350939

Coupling with G-proteins:
No information


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
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Laboratory