gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0308 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADRENOCEPTOR (B-ADRENOCEPTOR)
SUBFAMILY B1(Adrenoceptor)

Cross References:
UniProt Q9YHA7 EMBL AJ005437
InterPro IPR000332 | IPR000276 GPCRDB q9yha7_petma
PRINTS PR00237 PFAM PF00001

Details:
NAME ADRENOCEPTOR (B-ADRENOCEPTOR)_B1(Adrenoceptor)_Petromyzon marinus
DESCRIPTION Beta adrenoreceptor A .
SPECIES Petromyzon marinus COMMON NAME Sea lamprey NCBI Taxonomy 7757
GENE -
SEQUENCE
DVLCVTASIDTLCVIAVDRYIAVARPLRYETLMNKRRARFIIVAVWLVSALISFLPIEMG
WWKSEAAAAANNTAEDVCEFNISLEYAVASSSVSFYLPLTVMIILYSKVFREARKQDGKI
NTSEGRFYNNANDSATIKNPARKLSRFLSRKEHRALKTLGLIMGTFTLCWLPFFVVNIVQ
VVWNCVPTGVFVSLNWLGYINSAFNPIIYCRSPDFR
FRAGMENT YES

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12140284 | 12244098
HETERODIMER INFORMATION Forms heterodimers with B2 Adrenoceptors. Dimerization results in inhibiting internalization and ERK activation by B2 Adrenoceptor METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12244098
HETERODIMER INFORMATION Forms heterodimers with B2 Adrenoceptors. Dimerization results in inhibiting internalization and ERK activation by B2 Adrenoceptor METHOD Immunoprecipitation REFERENCES 12140284

Scaffold:
TYPE CN-ras-GEF( cAMP-depented Ras exchange factor) /nRAP-GEP/RA-GEF REFERENCES 12391161
TYPE Endophilin1-3( SH3p4,SH3p8,SH3p13) REFERENCES 10535961
TYPE GIPC( GAIP-interacting protein) REFERENCES 12724327
TYPE MAGI-2( membrane-associated guanylate kinase protein inverted 2) /S-SCAM REFERENCES 11526121
TYPE Nck, Grb3 REFERENCES 9843378 | 11384839
TYPE PSD95( postsynaptic density protein) REFERENCES 10995758

Coupling with G-proteins:
No information


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory