gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0307 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADRENOCEPTOR (B-ADRENOCEPTOR)
SUBFAMILY B1(Adrenoceptor)

Cross References:
UniProt P18090 EMBL J05561 | D00634
InterPro IPR000507 | IPR002233 | IPR000276 PDB 2FF9 GPCRDB adrb1_rat
GENEID 24925
PRINTS PR01103 | PR00561 | PR00237 PFAM PF00001

Details:
NAME ADRENOCEPTOR (B-ADRENOCEPTOR)_B1(Adrenoceptor)_Rattus norvegicus
DESCRIPTION Beta-1 adrenergic receptor (Beta-1 adrenoceptor) (Beta-1adrenoreceptor).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Adrb1 | Adrb1r
SEQUENCE 
MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAG
MGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITLPFRYQSLLTRARARALVC
TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLTGPPRPPSPAPSPSPGPPRPADSLANGRSSKRRP
SRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSA
FNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDD
DDDAGATPPARLLEPWAGCNGGTTTVDSDSSLDEPGRQGFSSESKV
 FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12140284 | 12244098
HETERODIMER INFORMATION Forms heterodimers with B2 Adrenoceptors. Dimerization results in inhibiting internalization and ERK activation by B2 Adrenoceptor METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12244098
HETERODIMER INFORMATION Forms heterodimers with B2 Adrenoceptors. Dimerization results in inhibiting internalization and ERK activation by B2 Adrenoceptor METHOD Immunoprecipitation REFERENCES 12140284

Scaffold:
TYPE CN-ras-GEF( cAMP-depented Ras exchange factor) /nRAP-GEP/RA-GEF REFERENCES 12391161
TYPE Endophilin1-3( SH3p4,SH3p8,SH3p13) REFERENCES 10535961
TYPE GIPC( GAIP-interacting protein) REFERENCES 12724327
TYPE MAGI-2( membrane-associated guanylate kinase protein inverted 2) /S-SCAM REFERENCES 11526121
TYPE Nck, Grb3 REFERENCES 9843378 | 11384839
TYPE PSD95( postsynaptic density protein) REFERENCES 10995758

Coupling with G-proteins:
Family:Gs REFERENCES:2825170
1GPR0124Galpha-s-Rattus norvegicus-2
2GPR0392Galpha-s-Rattus norvegicus-1

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athina University of Athens
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 Dept. of Cell Biology and Biophysics
Biophysics
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Laboratory