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gpDB::GPCR View
Entry 1 of 1 :: GPCR0305 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADRENOCEPTOR (B-ADRENOCEPTOR)
SUBFAMILY B1(Adrenoceptor)

Cross References:
UniProt O42574 EMBL Y09213
InterPro IPR000507 | IPR002233 | IPR000276 GPCRDB adrb1_xenla
GENEID 399337
PRINTS PR01103 | PR00561 | PR00237 PFAM PF00001

Details:
NAME ADRENOCEPTOR (B-ADRENOCEPTOR)_B1(Adrenoceptor)_Xenopus laevis
DESCRIPTION Beta-1 adrenergic receptor (Beta-1 adrenoceptor) (Beta-1adrenoreceptor) (X-BETA1AR).
SPECIES Xenopus laevis COMMON NAME African clawed frog NCBI Taxonomy 8355
GENE adrb1
SEQUENCE 
MGDGWGPMECRNRSGTPTTVPSPMHPLPELTHQWTMGMTMFMAAIILLIVMGNIMVIVAI
GRNQRLQTLTNVFITSLACADLIMGLFVVPLGATLVVSGRWLYGSIFCEFWTSVDVLCVT
ASIETLCVISIDRYIAITSPFRYQSLLTKGRAKGIVCSVWGISALVSFLPIMMHWWRDTG
DPLAMKCYEDPGCCDFVTNRAYAIASSIISFYFPLIIMIFVYIRVFKEAQKQMKKIDKCE
GRFSHSHVLSHGRSSRRILSKILVAKEQKALKTLGIIMGTFTLCWLPFFLANVVNVFYRN
LIPDKLFLFLNWLGYANSAFNPIIYCRSPDFRKAFKRLLCCPKKADRHLHTTGELSRYSG
GFVNSLDTNALGMCSECNGVRTSLD
 FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12140284 | 12244098
HETERODIMER INFORMATION Forms heterodimers with B2 Adrenoceptors. Dimerization results in inhibiting internalization and ERK activation by B2 Adrenoceptor METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12244098
HETERODIMER INFORMATION Forms heterodimers with B2 Adrenoceptors. Dimerization results in inhibiting internalization and ERK activation by B2 Adrenoceptor METHOD Immunoprecipitation REFERENCES 12140284

Scaffold:
TYPE CN-ras-GEF( cAMP-depented Ras exchange factor) /nRAP-GEP/RA-GEF REFERENCES 12391161
TYPE Endophilin1-3( SH3p4,SH3p8,SH3p13) REFERENCES 10535961
TYPE GIPC( GAIP-interacting protein) REFERENCES 12724327
TYPE MAGI-2( membrane-associated guanylate kinase protein inverted 2) /S-SCAM REFERENCES 11526121
TYPE Nck, Grb3 REFERENCES 9843378 | 11384839
TYPE PSD95( postsynaptic density protein) REFERENCES 10995758

Coupling with G-proteins:
Family:Gs REFERENCES:2825170
1GPR0127Galpha-s-Xenopus laevis

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athina University of Athens
 Faculty of Biology
 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory