gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2801 ::
CLASS FRIZZLED/SMOOTHENED
FAMILY SMOOTHENED
SUBFAMILY smoothened

Cross References:
UniProt Q99835 EMBL U84401 | AF114821 | AF114819 | AF114820 | AF120103 | AF071494 | BC009989
InterPro IPR000539 | IPR000024 | IPR015526 | IPR000832 GPCRDB smo_human
GENEID 6608 MIM 601500
PRINTS PR00489 PFAM PF01534 | PF01392

Details:
NAME SMOOTHENED_smoothened_Homo sapiens
DESCRIPTION Smoothened homolog precursor (SMO) (Gx protein).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE SMO | SMOH
SEQUENCE
MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP
LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA
VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN
EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV
TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT
MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF
HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI
RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW
ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA
TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV
AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE
ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG
AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL
MDADSDF
FRAGMENT NO

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Coupling with G-proteins:
Family:G12/13 REFERENCES:14723707
1GPR0034Galpha-12-Homo sapiens
2GPR0037Galpha-13-Homo sapiens
Family:Gi/o REFERENCES:10835429
3GPR0020Galpha-o1-Homo sapiens
4GPR0109Galpha-i3-Homo sapiens
5GPR0218Galpha-i1-Homo sapiens-1
6GPR0226Galpha-i2-Homo sapiens-2
7GPR0261Galpha-i1-Homo sapiens-2
8GPR0334Galpha-o-Homo sapiens
9GPR0365Galpha-i2-Homo sapiens-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory