gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0028 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY 5-HYDROXYTRYPTAMINE RECEPTOR
SUBFAMILY 5-HT-1B

Cross References:
UniProt Q16950 EMBL L43557
InterPro IPR015694 | IPR000276 GPCRDB 5htb1_aplca
PRINTS PR00237 PFAM PF00001

Details:
NAME 5-HYDROXYTRYPTAMINE RECEPTOR_5-HT-1B_Aplysia californica
DESCRIPTION 5-hydroxytryptamine receptor 1 (5-HTB1) (Serotonin receptor 1).
SPECIES Aplysia californica COMMON NAME California sea hare NCBI Taxonomy 6500
GENE 5HTB1
SEQUENCE
MKSLKSSTHDVPHPEHVVWAPPAYDEQHHLFFSHGTVLIGIVGSLIITVAVVGNVLVCLA
IFTEPILSHSKSNFFIVSLAVADLLLALLVMTFALVNDMYGYWLFGETFCFIWMSADVMC
ETASIFSICVISYDRLKQVQKPLHYEEFMTTTRALLIIACLWICSFVLSFVPIFLEWHEL
SVEEIKAIFKDNKTEKEKALEAHNFSSALNQTLGDNQKSNAKHVCLFDVHFTYSVIYSFI
CFYVPCTLMLTNYLRLFLIAQTHQVRIRSLQMTNPPQLRGQGASSYRNQGTQGSKAARTL
TIITGTFLACWLPFFIINPIAAADEHLIPLECFMVTIWLGYFNSSVNPIIYGTSNSKFRA
AFKRLLRCRSVKSVVGSISPVSPAYRAFSWIRPSRLDLSSSEHPSDACDTGRGKNSKGGD
CATADPTKPDVSVSEEIIYAGTKVFDSDTAFSS
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10452531
HETERODIMER INFORMATION Forms functional heterodimers when co-expressed with 5-HT-1D Receptor. METHOD Immunoprecipitation REFERENCES 10452531

Coupling with G-proteins:
No information


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory