gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2666 ::
CLASS CLASS C (METABOTROPIC GLUTAMATE / PHEROMONE)
FAMILY GLUTAMATE RECEPTOR (METABOTROPIC)
SUBFAMILY MGLU8

Cross References:
UniProt O00222 | O15493 | O95945 | O95946 | Q3MIV9 | Q52M02 | Q6J165 EMBL U92459 | U95025 | AJ236921 | AJ236922 | AY608335 | BC093725 | BC101675
InterPro IPR001828 | IPR000337 | IPR000162 | IPR000144 | IPR011500 GPCRDB grm8_human
GENEID 2918 MIM 601116
PRINTS PR00248 | PR01058 | PR00593 PFAM PF00003 | PF01094 | PF07562

Details:
NAME GLUTAMATE RECEPTOR (METABOTROPIC)_MGLU8_Homo sapiens
DESCRIPTION Metabotropic glutamate receptor 8 precursor (mGluR8).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE GRM8 | GPRC1H | MGLUR8
SEQUENCE
MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGER
GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV
QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA
PELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISR
EIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS
GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA
EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH
KDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN
KSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCER
CEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTF
VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMC
FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH
IIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEA
KPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYI
IIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTY
ISYSNHSI
FRAGMENT NO

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Scaffold:
TYPE PICK1( protein interacting with protein kinase) REFERENCES 12829238

Coupling with G-proteins:
Family:Gi/o REFERENCES:9473604
1GPR0020Galpha-o1-Homo sapiens
2GPR0109Galpha-i3-Homo sapiens
3GPR0218Galpha-i1-Homo sapiens-1
4GPR0226Galpha-i2-Homo sapiens-2
5GPR0261Galpha-i1-Homo sapiens-2
6GPR0334Galpha-o-Homo sapiens
7GPR0365Galpha-i2-Homo sapiens-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory