gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2662 ::
CLASS CLASS C (METABOTROPIC GLUTAMATE / PHEROMONE)
FAMILY GLUTAMATE RECEPTOR (METABOTROPIC)
SUBFAMILY MGLU7

Cross References:
UniProt Q14831 | Q8NFS2 | Q8NFS3 | Q8NFS4 EMBL X94552 | U92458 | AF458052 | AF458053 | AF458054
InterPro IPR001828 | IPR000337 | IPR000162 | IPR001883 | IPR011500 GPCRDB grm7_human
GENEID 2917 MIM 604101
PRINTS PR00248 | PR01057 | PR00593 PFAM PF00003 | PF01094 | PF07562

Details:
NAME GLUTAMATE RECEPTOR (METABOTROPIC)_MGLU7_Homo sapiens
DESCRIPTION Metabotropic glutamate receptor 7 precursor (mGluR7).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE GRM7 | GPRC1G | MGLUR7
SEQUENCE
MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAK
GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL
TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA
STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ
ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK
RADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR
NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAH
ALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIF
QYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP
CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAML
GIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRV
FLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW
FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGV
PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML
YMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS
PAAKKKYVSYNNLVI
FRAGMENT NO

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Scaffold:
TYPE alpha-filamin/ABP280( actin binding protein 280) REFERENCES 12570872
TYPE GRIP1( glutamate receptor interacting protein 1) REFERENCES 11891216
TYPE GRIP1( glutamate receptor interacting protein 1) REFERENCES 11891216
TYPE PICK1( protein interacting with protein kinase) REFERENCES 11891216
TYPE Syntenin REFERENCES 12570872 | 1189121

Coupling with G-proteins:
Family:Gi/o REFERENCES:8288585
1GPR0020Galpha-o1-Homo sapiens
2GPR0109Galpha-i3-Homo sapiens
3GPR0218Galpha-i1-Homo sapiens-1
4GPR0226Galpha-i2-Homo sapiens-2
5GPR0261Galpha-i1-Homo sapiens-2
6GPR0334Galpha-o-Homo sapiens
7GPR0365Galpha-i2-Homo sapiens-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory