gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2655 ::
CLASS CLASS C (METABOTROPIC GLUTAMATE / PHEROMONE)
FAMILY GLUTAMATE RECEPTOR (METABOTROPIC)
SUBFAMILY MGLU3

Cross References:
UniProt P31422 EMBL M92076
InterPro IPR001828 | IPR000337 | IPR000162 | IPR001234 | IPR011500 PDB 2E4U | 2E4V | 2E4W | 2E4X | 2E4Y GPCRDB grm3_rat
GENEID 24416
PRINTS PR00248 | PR01053 | PR00593 PFAM PF00003 | PF01094 | PF07562

Details:
NAME GLUTAMATE RECEPTOR (METABOTROPIC)_MGLU3_Rattus norvegicus
DESCRIPTION Metabotropic glutamate receptor 3 precursor (mGluR3).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Grm3 | Gprc1c | Mglur3
SEQUENCE
MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRI
NEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV
DEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSD
KSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNIC
IATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVAS
DGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ
CSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD
AMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSY
LKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL
VDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIK
HNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALL
TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLP
EKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCI
IWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLH
LNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL
FRAGMENT NO

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Scaffold:
TYPE GRIP1( glutamate receptor interacting protein 1) REFERENCES 11891216
TYPE PICK1( protein interacting with protein kinase) REFERENCES 12829238
TYPE Syntenin REFERENCES 11891216
TYPE Tamalin/GRASP REFERENCES

Coupling with G-proteins:
Family:Gi/o REFERENCES:1309649
1GPR0026Galpha-o-Rattus norvegicus
2GPR0111Galpha-i3-Rattus norvegicus
3GPR0221Galpha-i1-Rattus norvegicus
4GPR0229Galpha-i2-Rattus norvegicus


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory