gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2645 ::
CLASS CLASS C (METABOTROPIC GLUTAMATE / PHEROMONE)
FAMILY GABA RECEPTOR
SUBFAMILY GABA-B-R2

Cross References:
UniProt O75899 | O75974 | O75975 | Q5VXZ2 | Q8WX04 | Q9P1R2 | Q9UNR1 | Q9UNS9 EMBL AJ012188 | AF069755 | AF099033 | AF056085 | AF095784 | AF074483 | AL445495 | AL353782 | AL356282 | AL591502 | AL353782 | AL356282 | AL445495 | AL591502 | AL356282 | AL353782 | AL445495 | AL591502 | AL591502 | AL353782 | AL356282 | AL445495 | BC035071
InterPro IPR001828 | IPR000337 | IPR002455 | IPR002457 GPCRDB gabr2_human
GENEID 9568 MIM 607340
PRINTS PR01178 | PR01176 | PR00248 PFAM PF00003 | PF01094

Details:
NAME GABA RECEPTOR_GABA-B-R2_Homo sapiens
DESCRIPTION Gamma-aminobutyric acid type B receptor subunit 2 precursor (GABA-Breceptor 2) (GABA-B-R2) (Gb2) (GABABR2) (G-protein coupled receptor51) (HG20).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE GABBR2 | GPR51 | GPRC3B
SEQUENCE
MASPRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMG
LMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDA
IKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDN
AVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSV
KKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSS
RCLRKNLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYD
GIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNG
ERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLP
LYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLD
GSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVI
VGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIV
YAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQ
FCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSV
NQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNL
GNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILH
HAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL
FRAGMENT NO

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Dimerization:
HETERODIMER INFORMATION Forms heterodimers with GABA-B-R1 Receptors. Upon dimerization, GABA-B-R2 serves as a molecular chaperone for GABA-B-R1 and is required for full receptor function METHOD Immunoprecipitation, functional reconstitution REFERENCES 9872315 | 9872317 | 9872316

Scaffold:
TYPE Syntenin REFERENCES 11891216

Coupling with G-proteins:
Family:Gi/o REFERENCES:9872315
1GPR0020Galpha-o1-Homo sapiens
2GPR0109Galpha-i3-Homo sapiens
3GPR0218Galpha-i1-Homo sapiens-1
4GPR0226Galpha-i2-Homo sapiens-2
5GPR0261Galpha-i1-Homo sapiens-2
6GPR0334Galpha-o-Homo sapiens
7GPR0365Galpha-i2-Homo sapiens-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory