| Details: |
| NAME |
GABA RECEPTOR_GABA-B-R1_Rattus norvegicus |
| DESCRIPTION |
Gamma-aminobutyric acid type B receptor subunit 1 precursor (GABA-Breceptor 1) (GABA-B-R1) (Gb1). |
| SPECIES |
Rattus norvegicus |
COMMON NAME |
Rat |
NCBI Taxonomy |
10116 |
| GENE |
Gabbr1 |
| SEQUENCE |
MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDY
EIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPA
LDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGG
WPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKII
LMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLF
EKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARI
IVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEG
HITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALAL
NKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQ
LQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSL
GIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPF
VCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMD
VLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGELWSFAVSSD
VQRRATVGGDSPICVWPAPESIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIY
NVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSET
QDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPT
PPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK
|
FRAGMENT |
NO
|
|
|
|
|
Homepage
|
| Dimerization: |
| HETERODIMER INFORMATION |
Forms heterodimers with GABA-B-R2 Receptors. Upon dimerization, GABA-B-R2 serves as a molecular chaperone for GABA-B-R1 and is required for full receptor function
|
METHOD |
Immunoprecipitation, functional reconstitution
|
REFERENCES |
9872315 | 9872317 | 9872316
|
| Scaffold: |
| TYPE |
14-3-3 heta
|
REFERENCES |
11178869
|
| TYPE |
17-3-3 ksi
|
REFERENCES |
11178869
|
| Coupling with G-proteins: |
| Family:Gi/o |
REFERENCES: | 9872315 | | 1 | GPR0026 | Galpha-o-Rattus norvegicus | | 2 | GPR0111 | Galpha-i3-Rattus norvegicus | | 3 | GPR0221 | Galpha-i1-Rattus norvegicus | | 4 | GPR0229 | Galpha-i2-Rattus norvegicus |
|
biol.uoa.gr
for comments, corrections and
data (sequence) submission.
