gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2638 ::
CLASS CLASS C (METABOTROPIC GLUTAMATE / PHEROMONE)
FAMILY EXTRACELLULAR CALCIUM-SENSING RECEPTOR
SUBFAMILY CASR

Cross References:
UniProt O62714 | O62715 | O62716 EMBL AF041025 | AF041026 | AF041027
InterPro IPR000337 | IPR015531 GPCRDB casr_pig
PRINTS PR00248 PFAM PF00003

Details:
NAME EXTRACELLULAR CALCIUM-SENSING RECEPTOR_CASR_Sus scrofa
DESCRIPTION Extracellular calcium-sensing receptor .
SPECIES Sus scrofa COMMON NAME Pig NCBI Taxonomy 9823
GENE CASR | PCAR1
SEQUENCE
CPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGAFIKFRNTPIVK
ATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVAC
IFFNKVYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRQRSSSLGGSTGSQQQ
PRCKQKVIFGSGTVTFSLSFHEPQKNAM
FRAGMENT YES

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12383267
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Functional complementation of inactive mutant receptors REFERENCES 9722601
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10077597
HETERODIMER INFORMATION Forms heterodimers with Metabotropic Glutamate Receptor 1. METHOD Immunoprecipitation REFERENCES 11489900
HETERODIMER INFORMATION Forms heterodimers with Metabotropic Glutamate Receptor 5. METHOD Immunoprecipitation REFERENCES 11489900

Scaffold:
TYPE alpha-filamin/ABP280( actin binding protein 280) REFERENCES 11390380 | 1223909

Coupling with G-proteins:
No information


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