gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2493 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY SOMATOSTATIN RECEPTOR
SUBFAMILY SST5

Cross References:
UniProt Q8QGQ4 EMBL AF252879
InterPro IPR000276 | IPR000586 | IPR001184 GPCRDB q8qgq4_carau
PRINTS PR00237 | PR00246 | PR00591 PFAM PF00001

Details:
NAME SOMATOSTATIN RECEPTOR_SST5_Carassius auratus
DESCRIPTION Type five-like somatostatin receptor.
SPECIES Carassius auratus COMMON NAME Goldfish NCBI Taxonomy 7957
GENE -
SEQUENCE 
MATQGSMCNTSISDYANQSNEFNNTFHQLNGSSMAEEDSTKILAVIYLVVFVVGLTGNSL
AIFVVLRYTKMKTATNMYILNLAVADELYILGLPFLTAHNMLGYWPFGNFLCRILMWTDS
ISQFTSTFCLTVMSIDRYMAVVHPIRSARWRRPRVAKVINSMVWALSCLLTLPVIIYCDV
QPELNTCNLSWPEPRDVWSTAFILYTAMLGFFFPLMVICLCYLLIVIKVKSASARAGLSK
RGRSEKKVTRMVVIIVVVFVLCWLPFFIINILNLISTLPENSLMTGIYFLTVILTYVNSC
ANPLLYSFLSDNFKRSFQQVLCIHKVNGVSNGHPGREHLSRSQQNEAFFPPRSFDFNNHV
QTYQSIGLKAEACDKLENHRPGPQPSSQSI
 FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation, Fluorescence Resonance Energy Transfer (FRET) REFERENCES 10713101
HETERODIMER INFORMATION Forms heterodimer with SST1 Receptor. Dimerization allows internalization of SST1 Receptor METHOD Photobleaching Fluorescence Resonance Energy Transfer (FRET) REFERENCES 10713101
HETERODIMER INFORMATION Forms heterodimer with Dopamine Receptor D2. Dimerization results in increased ligand binding affnity and enhanced signalling METHOD Photobleaching Fluorescence Resonance Energy Transfer (FRET) REFERENCES 10753124

Coupling with G-proteins:
No information

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athina University of Athens
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 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory