gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2484 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY SOMATOSTATIN RECEPTOR
SUBFAMILY SST3

Cross References:
UniProt P30936 EMBL X63574
InterPro IPR000276 | IPR000586 | IPR001856 GPCRDB ssr3_rat
GENEID 171044
PRINTS PR00237 | PR00246 | PR00589 PFAM PF00001

Details:
NAME SOMATOSTATIN RECEPTOR_SST3_Rattus norvegicus
DESCRIPTION Somatostatin receptor type 3 (SS3R) (SSR-28).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Sstr3
SEQUENCE
MAAVTYPSSVPTTLDPGNASSAWPLDTSLGNASAGTSLAGLAVSGILISLVYLVVCVVGL
LGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLV
MAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARMVSAAVWVASAVVVLPVV
VFSGVPRGMSTCHMQWPEPAAAWRTAFIIYTAALGFFGPLLVICLCYLLIVVKVRSTTRR
VRAPSCQWVQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPEEPAF
FGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRVRSQEPGSGPPEKTEEE
EDEEEEERREEEERRMQRGQEMNGRLSQIAQPGPSGQQQRPCTGTAKEQQLLPQEATAGD
KASTLSHL
FRAGMENT NO

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Dimerization:
HETERODIMER INFORMATION Forms heterodimer with SST2 Receptor. Dimerization results in inactivation of SST3 Receptor function METHOD Immunoprecipitation REFERENCES 11134004

Coupling with G-proteins:
Family:Gi/o REFERENCES:1337145
1GPR0026Galpha-o-Rattus norvegicus
2GPR0111Galpha-i3-Rattus norvegicus
3GPR0221Galpha-i1-Rattus norvegicus
4GPR0229Galpha-i2-Rattus norvegicus


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory