gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2476 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY SOMATOSTATIN RECEPTOR
SUBFAMILY SST1

Cross References:
UniProt P28646 EMBL X62314 | M97656
InterPro IPR000276 | IPR000586 | IPR001116 GPCRDB ssr1_rat
GENEID 25033
PRINTS PR00237 | PR00246 | PR00587 PFAM PF00001

Details:
NAME SOMATOSTATIN RECEPTOR_SST1_Rattus norvegicus
DESCRIPTION Somatostatin receptor type 1 (SS1R) (SRIF-2).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Sstr1
SEQUENCE
MFPNGTAPSPTSSPSSSPGGCGEGVCSRGPGSGAADGMEEPGRNSSQNGTLSEGQGSAIL
ISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLL
RHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLG
VWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAIC
LCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQD
DATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKS
RAYSVEDFQPENLESGGVFRNGTCASRISTL
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation, Fluorescence Resonance Energy Transfer (FRET) REFERENCES 10713101
HETERODIMER INFORMATION Forms heterodimer with SST5 Receptor. Dimerization allows internalization of SST1 Receptor METHOD Photobleaching Fluorescence Resonance Energy Transfer (FRET) REFERENCES 10713101

Coupling with G-proteins:
Family:Gi/o REFERENCES:1346068
1GPR0026Galpha-o-Rattus norvegicus
2GPR0111Galpha-i3-Rattus norvegicus
3GPR0221Galpha-i1-Rattus norvegicus
4GPR0229Galpha-i2-Rattus norvegicus


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athina University of Athens
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Biophysics
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Laboratory