gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0024 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY 5-HYDROXYTRYPTAMINE RECEPTOR
SUBFAMILY 5-HT-1B

Cross References:
UniProt O08892 EMBL U82175
InterPro IPR002147 | IPR002231 | IPR000276 GPCRDB 5ht1b_cavpo
PRINTS PR00513 | PR01101 | PR00237 PFAM PF00001

Details:
NAME 5-HYDROXYTRYPTAMINE RECEPTOR_5-HT-1B_Cavia porcellus
DESCRIPTION 5-hydroxytryptamine receptor 1B (5-HT-1B) (Serotonin receptor 1B) (5-HT1B).
SPECIES Cavia porcellus COMMON NAME Guinea pig NCBI Taxonomy 10141
GENE HTR1B
SEQUENCE
MGNPEASCTPPAVLGSQTGLPHANVSAPPNNCSAPSHIYQDSIALPWKVLLVVLLALITL
ATTLSNAFVIATVYRTRKLHTPANYLIASLAFTDLLVSILVMPISTMYTVTGRWTLGQAL
CDFWLSSDITCCTASIMHLCVIALDRYWAITDAVGYSAKRTPRRAAGMIALVWVFSICIS
LPPFFWRQAKAEEEVLDCLVNTDHVLYTVYSTGGAFYLPTLLLIALYGRIYVEARSRILK
QTPNKTGKRLTRAQLITDSPGSTSSVTSINSRAPEVPCDSGSPVYVNQVKVRVSDALLEK
KKLMAARERKATKTLGVILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFTWLGYLN
SLINPIIYTMSNEDFKQAFHKLIRFKCTT
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10452531
HETERODIMER INFORMATION Forms functional heterodimers when co-expressed with 5-HT-1D Receptor. METHOD Immunoprecipitation REFERENCES 10452531

Coupling with G-proteins:
Family:Gi/o REFERENCES:1351684
1GPR0107Galpha-i3-Cavia porcellus
2GPR0216Galpha-i1-Cavia porcellus
3GPR0224Galpha-i2-Cavia porcellus


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athina University of Athens
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