| Details: |
| NAME |
ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2A(Adrenoceptor)_Rattus norvegicus |
| DESCRIPTION |
Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2Aadrenoreceptor) (Alpha-2AAR) (CA2-47) (Alpha-2D adrenergic receptor). |
| SPECIES |
Rattus norvegicus |
COMMON NAME |
Rat |
NCBI Taxonomy |
10116 |
| GENE |
Adra2a |
| SEQUENCE |
MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFT
SRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSS
IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGG
QQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACS
APPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSE
HAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKAS
RWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSS
LNPVIYTIFNHDFRRAFKKILCRGDRKRIV
|
FRAGMENT |
NO
|
|
|
|
|
Homepage
|
| Dimerization: |
| HETERODIMER INFORMATION |
Forms heterodimers with B1 Adrenoceptors. Heterodimerization results in altered ligand binding and internalization of the receptor
|
METHOD |
Immunoprecipitation
|
REFERENCES |
12529373
|
| Scaffold: |
| TYPE |
14-3-3 ksi
|
REFERENCES |
10224112
|
| TYPE |
Spinophilin/neurabin II
|
REFERENCES |
11154706
|
| Coupling with G-proteins: |
| Family:Gi/o |
REFERENCES: | 8662784 | | 1 | GPR0026 | Galpha-o-Rattus norvegicus | | 2 | GPR0111 | Galpha-i3-Rattus norvegicus | | 3 | GPR0221 | Galpha-i1-Rattus norvegicus | | 4 | GPR0229 | Galpha-i2-Rattus norvegicus | | Family:Gq/11 |
REFERENCES: | 8662784 | | 5 | GPR0032 | Galpha-11-Rattus norvegicus | | 6 | GPR0242 | Galpha-q-Rattus norvegicus | | Family:Gs |
REFERENCES: | 8662784 | | 7 | GPR0124 | Galpha-s-Rattus norvegicus-2 | | 8 | GPR0392 | Galpha-s-Rattus norvegicus-1 |
|
biol.uoa.gr
for comments, corrections and
data (sequence) submission.
