gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0217 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADRENOCEPTOR (A1-ADRENOCEPTOR)
SUBFAMILY A1B(Adrenoceptor)

Cross References:
UniProt P18841 EMBL J04084
InterPro IPR001115 | IPR002233 | IPR000276 GPCRDB ada1b_mesau
PRINTS PR01103 | PR00556 | PR00237 PFAM PF00001

Details:
NAME ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1B(Adrenoceptor)_Mesocricetus auratus
DESCRIPTION Alpha-1B adrenergic receptor (Alpha 1B-adrenoceptor) (Alpha 1B-adrenoreceptor).
SPECIES Mesocricetus auratus COMMON NAME Golden hamster NCBI Taxonomy 10036
GENE ADRA1B
SEQUENCE
MNPDLDTGHNTSAPAQWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAI
VGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDI
WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFM
RILGCQCRSGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGSQRTLP
SASPSPGYLGRGAQPPLELCAYPEWKSGALLSLPEPPGRRGRLDSGPLFTFKLLGEPESP
GTEGDASNGGCDATTDLANGQPGFKSNMPLAPGHF
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation, Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12888550
HETERODIMER INFORMATION Forms heterodimers with A1A Adrenoceptors. Heterodimerization results in altered internalization of the receptor METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12888550

Scaffold:
TYPE nNOS( neuronal nitric oxide synthase) NOS1 REFERENCES 12184796

Coupling with G-proteins:
No information


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory