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gpDB::GPCR View
Entry 1 of 1 :: GPCR0204 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADRENOCEPTOR (A1-ADRENOCEPTOR)
SUBFAMILY A1A(Adrenoceptor)

Cross References:
UniProt O02824 EMBL U81982
InterPro IPR001004 | IPR002233 | IPR000276 GPCRDB ada1a_rabit
GENEID 100009237
PRINTS PR01103 | PR00557 | PR00237 PFAM PF00001

Details:
NAME ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1A(Adrenoceptor)_Oryctolagus cuniculus-1
DESCRIPTION Alpha-1A adrenergic receptor (Alpha 1A-adrenoceptor) (Alpha 1A-adrenoreceptor) (Alpha-1C adrenergic receptor).
SPECIES Oryctolagus cuniculus COMMON NAME Rabbit NCBI Taxonomy 9986
GENE ADRA1A | ADRA1C
SEQUENCE
MVFLSGNASDSSNCTHPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIISLCVI
SIDRYIGVSYPLRYPTIVTQRRGLRALLCVWAFSLVISVGPLFGWRQPAPDDETICQINE
EPGYVLFSALGSFYVPLTIILAMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
APAGGSGVASAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLKIQCLRRKQSSKHALGYTL
HAPSQALEGQHKDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPRGSARITVPKDQSACT
TARVRSKSFLQVCCCVGPSTPNPGENHQVPTIKIHTISLSENGEEV
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation, Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12888550
HETERODIMER INFORMATION Forms heterodimers with A1B Adrenoceptors. Heterodimerization results in altered internalization of the receptor METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12888550

Scaffold:
TYPE nNOS( neuronal nitric oxide synthase) NOS1 REFERENCES 12184796

Coupling with G-proteins:
No information


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory