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gpDB::GPCR View
Entry 1 of 1 :: GPCR0199 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADRENOCEPTOR (A1-ADRENOCEPTOR)
SUBFAMILY A1A(Adrenoceptor)

Cross References:
UniProt Q91175 EMBL D63859
InterPro IPR001004 | IPR002233 | IPR000276 | IPR001991 GPCRDB ada1a_oryla
PRINTS PR01103 | PR00173 | PR00237 PFAM PF00001

Details:
NAME ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1A(Adrenoceptor)_Oryzias latipes
DESCRIPTION Alpha-1A adrenergic receptor (Alpha 1A-adrenoceptor) (Alpha 1A-adrenoreceptor) (MAR1).
SPECIES Oryzias latipes COMMON NAME Medaka fish NCBI Taxonomy 8090
GENE adra1a
SEQUENCE
MTPSSVTLNCSNCSHVLAPELNTVKAVVLGMVLGIFILFGVIGNILVILSVVCHRHLQTV
TYYFIVNLAVADLLLSSTVLPFSAIFEILDRWVFGRVFCNIWAAVDVLCCTASIMSLCVI
SVDRYIGVSYPLRYPAIMTKRRALLAVMLLWVLSVIISIGPLFGWKEPAPEDETVCKITE
EPGYAIFSAVGSFYLPLAIILAMYCRVYVVAQKESRGLKEGQKIEKSDSEQVILRMHRGN
TTVSEDEALRSRTHFALRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVLPIGSIFPAYR
PSDTVFKITFWLGYFNSCINPIIYLCSNQEFKKAFQSLLGVHCLRMTPRAHHHHLSVGQS
QTQGHSLTISLDSKGAPCRLSPSSSVALSRTPSSRDSREWRVFSGGPINSGPGPTEAGRA
KVAKLCNKSLHRTCCCILRARTPTQDPAPLGDLPTIKIHQLSLSEKGESV
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation, Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12888550
HETERODIMER INFORMATION Forms heterodimers with A1B Adrenoceptors. Heterodimerization results in altered internalization of the receptor METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12888550

Scaffold:
TYPE nNOS( neuronal nitric oxide synthase) NOS1 REFERENCES 12184796

Coupling with G-proteins:
No information


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory