gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR1883 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY OPIOID AND OPIOID-LIKE RECEPTOR
SUBFAMILY DELTA OPIOID PEPTIDE (DOR)

Cross References:
UniProt P79291 EMBL U71149
InterPro IPR000321 | IPR000276 | IPR001418 GPCRDB oprd_pig
PRINTS PR00525 | PR00237 | PR00384 PFAM PF00001

Details:
NAME OPIOID AND OPIOID-LIKE RECEPTOR_DELTA OPIOID PEPTIDE (DOR)_Sus scrofa
DESCRIPTION Delta-type opioid receptor .
SPECIES Sus scrofa COMMON NAME Pig NCBI Taxonomy 9823
GENE OPRD1
SEQUENCE
GIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNM
FTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPR
DGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILVITVCYGLMLLRLRSVRLLSGSKEK
DRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
FRAGMENT YES

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET), Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) REFERENCES 12217652 | 11278447
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 9341132 | 10842167
HETERODIMER INFORMATION Forms heterodimers with kappa Opioid Peptide Receptor. Dimerization results in altered ligand binding, potentiated signalling and altered internalization METHOD Immunoprecipitation REFERENCES 10385123
HETERODIMER INFORMATION Forms heterodimers with mu Opioid Peptide Receptor. Dimerization results in Changing the binding properties of opiate ligands and altered G-protein coupling METHOD Immunoprecipitation REFERENCES 10842167 | 11069979
HETERODIMER INFORMATION Forms heterodimers with B2 Adrenoceptors. Heterodimerization results in altered internalization and MAPK signalling METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET), Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) REFERENCES 11134510 | 11278447

Scaffold:
TYPE GASP( GPCR associated sorting protein) REFERENCES 12142540

Coupling with G-proteins:
No information


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory