gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0128 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ACETYLCHOLINE RECEPTOR (MUSCARINIC)
SUBFAMILY M2

Cross References:
UniProt P41985 | Q3Y686 EMBL DQ154113 | L27102
InterPro IPR000276 | IPR001065 | IPR000995 GPCRDB acm2_bovin
GENEID 522170
PRINTS PR00237 | PR00243 | PR00539 PFAM PF00001

Details:
NAME ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M2_Bos taurus
DESCRIPTION Muscarinic acetylcholine receptor M2.
SPECIES Bos taurus COMMON NAME Bovine NCBI Taxonomy 9913
GENE CHRM2
SEQUENCE 
MNNSTNSSNNVALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYF
LFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDR
YFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFF
SNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIV
KPNNNNMPGSDDGLEHNKIQNGKTPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDEI
TQDENTVSTSVGHSKDENSKQTCIKIVTKTPKGDQCTPTNTTVELVGSSGQNGDEKQNIV
ARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTV
WTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
 FRAGMENT NO

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Dimerization:
HETERODIMER INFORMATION Forms heterodimers with Muscarinic M3 Receptors. Heterodimerization results in altered internalization of the receptors METHOD Chimeric receptor reconstitution studies REFERENCES 10490911

Coupling with G-proteins:
Family:Gi/o REFERENCES:3443095
1GPR0017Galpha-o1-Bos taurus
2GPR0219Galpha-i1-Bos taurus
3GPR0294Galpha-i2-Bos taurus-2
4GPR0295Galpha-i2-Bos taurus-1

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