gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0124 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ACETYLCHOLINE RECEPTOR (MUSCARINIC)
SUBFAMILY M2

Cross References:
UniProt Q9N2A5 EMBL AB041394
InterPro IPR000276 | IPR001065 | IPR000995 GPCRDB q9n2a5_ponpy
PRINTS PR00237 | PR00243 | PR00539 PFAM PF00001

Details:
NAME ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M2_Pongo pygmaeus
DESCRIPTION Muscarinic acetylcholine receptor m2 .
SPECIES Pongo pygmaeus COMMON NAME Orangutan NCBI Taxonomy 9600
GENE CHRM2
SEQUENCE
VLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVI
GYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAA
AWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLY
WHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAP
RDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIR
IGTKTPKIDSCTSTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVT
RTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNAT
FKKTFKHLLMCHYKNIGATR
FRAGMENT YES

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Dimerization:
HETERODIMER INFORMATION Forms heterodimers with Muscarinic M3 Receptors. Heterodimerization results in altered internalization of the receptors METHOD Chimeric receptor reconstitution studies REFERENCES 10490911

Coupling with G-proteins:
No information


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athina University of Athens
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Biophysics
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