gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::GPCR View
Entry 1 of 1 :: GPCR1220 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY MELATONIN RECEPTOR
SUBFAMILY MT1

Cross References:
UniProt O02769 EMBL U73327
InterPro IPR000276 | IPR002278 | IPR000025 GPCRDB mtr1a_bovin
PRINTS PR00237 | PR01149 | PR00857 PFAM PF00001

Details:
NAME MELATONIN RECEPTOR_MT1_Bos taurus
DESCRIPTION Melatonin receptor type 1A .
SPECIES Bos taurus COMMON NAME Bovine NCBI Taxonomy 9913
GENE MTNR1A
SEQUENCE 
YPLALASIVNDGWSLSSLHCQLSGFLMGLSVIGSVFNITGIAINRYCCICHSLRYNKLYS
STNSLCYVFLIWMLTLVAIVPNLCVGTLQYDPRIYSCTFTQSVSSAYTIAVVVFHFIVPM
LVVIFCYLRIWALVLQVRWRVKPDNKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLV
VASEPASMAPRIPEWLFVASYYMGYFNSCLNAIIYGLLNQNFRQEYRKIIVSLCTTKMFF
VDSSNHVAHRIKRKPSP
 FRAGMENT YES

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11940583
HETERODIMER INFORMATION Forms heterodimers with Melatonin MT2 Receptors. METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11940583

Coupling with G-proteins:
Family:Gi/o REFERENCES:7946354
1GPR0017Galpha-o1-Bos taurus
2GPR0219Galpha-i1-Bos taurus
3GPR0294Galpha-i2-Bos taurus-2
4GPR0295Galpha-i2-Bos taurus-1

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