gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::Effector View
Entry 1 of 1 :: EFF0698 ::
FAMILY Guanine nucleotide releasing factors
SUBFAMILY Ras specific nucleotide releasing factors
TYPE Ras specific nucleotide exchange factor CDC25

Cross References:
UniProt P27671 EMBL L20899 | X59868
InterPro IPR000219 | IPR001331 | IPR000048 | IPR001849 | IPR011993 | IPR008937 | IPR000651 | IPR001895 PDB 2IJE
GENEID 19417
PFAM PF00612 | PF00169 | PF00617 | PF00618 | PF00621

Details:
NAME Ras specific nucleotide exchange factor CDC25-Mus musculus-2
DESCRIPTION Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guaninenucleotide-releasing protein) (GNRP) (Ras-specific nucleotide exchangefactor CDC25) (CDC25Mm).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Rasgrf1 | Cdc25 | Grf1
SEQUENCE 
MQKAIRLNDGHVVTLGLLAQKDGTRKGYLSKRSADNPKWQTKWFALLQNLLFYFESDSSP
RPSGLYLLEGSICKRAPSPKRGTSSKESGEKQQHYFTVNFSNDSQKTLELRTEDAKDCDE
WVAAIARASYKILATEHEALMQKYLHLLQVVETEKTVAKQLRQQLEDGEVEIERLKTEVT
ITNLIKDNDRIQSSNKAGSADDEDSDIKKIKKVQSFLRGWLCRRKWKNIIQDYIRSPHAD
SMRKRNQVVFSMLEA
 FRAGMENT NO
FUNCTION Promotes the exchange of Ras-bound GDP by GTP
Interacting with G-proteins:
Family:Gbeta REFERENCES:15251227 | 8717044
1GPR0148Gbeta-1-Mus musculus
2GPR0156Gbeta-2-Mus musculus
3GPR0161Gbeta-3-Mus musculus
4GPR0165Gbeta-4-Mus musculus
5GPR0168Gbeta-5-Mus musculus-2
6GPR0291unclassified_Gbeta-Mus musculus-1
7GPR0318unclassified_Gbeta-Mus musculus-2
8GPR0376Gbeta-5-Mus musculus-3
9GPR0377Gbeta-5-Mus musculus-1
Family:Ggamma REFERENCES:15251227 | 8717044
10GPR0178Ggamma-t1-Mus musculus
11GPR0181Ggamma-2-Mus musculus
12GPR0184Ggamma-3-Mus musculus
13GPR0186Ggamma-4-Mus musculus
14GPR0189Ggamma-5-Mus musculus
15GPR0193Ggamma-7-Mus musculus
16GPR0196Ggamma-8-Mus musculus-2
17GPR0200Ggamma-11-Mus musculus
18GPR0204Ggamma-12-Mus musculus
19GPR0206Ggamma-13-Mus musculus
20GPR0211Ggamma-8-Mus musculus-1
21GPR0349Ggamma-1-Mus musculus
22GPR0379Ggamma-10-Mus musculus

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athina University of Athens
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 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory