gpDB: a database of G-proteins and their interaction with GPCRs
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gpDB::Effector View
Entry 1 of 1 :: EFF0594 ::
FAMILY PI3/PI4 kinases
SUBFAMILY Class Ib PI3Ks
TYPE PI3K gamma

Cross References:
UniProt O02697 EMBL Y10743
InterPro IPR000403 | IPR002420 | IPR000341 | IPR001263 | IPR015433 PDB 1E7U | 1E7V | 1E8W | 1E8X | 1E90
GENEID 396979
PFAM PF00454 | PF00792 | PF00794 | PF00613

Details:
NAME PI3K gamma-Sus scrofa
DESCRIPTION Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaisoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3-kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).
SPECIES Sus scrofa COMMON NAME Pig NCBI Taxonomy 9823
GENE PIK3CG
SEQUENCE
MELENYEQPVVLREDNRRRRRRMKPRSTAASLSSMELIPIEFVLPTSQRNTKTPETALLH
VAGHGNVEQMKAQVWLRALETSVSADFYHRLGPDHFLLLYQKKGQWYEIYDKYQVVQTLD
CLRYWKVLHRSPGQIHVVQRHAPSEETLAFQRQLNALIGYDVTDVSNVHDDELEFTRRRL
VTPRMAEVAGRDPKLYAMHPWVTSKPLPEYLLKKITNNCVFIVIHRSTTSQTIKVSADDT
PGTILQSFFTKMAKK
FRAGMENT NO
FUNCTION 3-phosphorylates the cellular phosphoinositide PtdIns-s 4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5-s triiphosphate (PtdIns(3,4,5)P3)
Interacting with G-proteins:
No information


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athina University of Athens
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Biophysics
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Laboratory