gpDB::Effector View

gpDB: a database of G-proteins and their interaction with GPCRs

gpDB::Effector View

Entry 1 of 1 :: EFF0365 ::

FAMILY	Ser Thr protein kinases
SUBFAMILY	G protein coupled receptor kinases
TYPE	GRK4

Cross References:
UniProt	P32298 \| O00641 \| O00642 \| Q13293 \| Q13294 \| Q13295 \| Q14453 \| Q14725	EMBL	L03718 \| X97879 \| X97880 \| X97881 \| U33054 \| U33055 \| U33056 \| U33168 \| U33153 \| U33155 \| U33156 \| U33157 \| U33158 \| U33159 \| U33160 \| U33161 \| U33162 \| U33163 \| U33164 \| U33165 \| U33166 \| U33167 \| U33168 \| U33153 \| U33154 \| U33155 \| U33156 \| U33157 \| U33158 \| U33159 \| U33160 \| U33161 \| U33162 \| U33163 \| U33164 \| U33165 \| U33
InterPro	IPR000239 \| IPR000961 \| IPR000719 \| IPR000342 \| IPR008271 \| IPR002290
PRODOM	PD000001	GENEID	2868	MIM	137026
PRINTS	PR00717	PFAM	PF00069 \| PF00615

Details:
NAME	GRK4-Homo sapiens
DESCRIPTION	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupledreceptor kinase GRK4) (ITI1).
SPECIES	Homo sapiens	COMMON NAME	Human	NCBI Taxonomy	9606
GENE	GRK4 \| GPRK2L \| GPRK4
SEQUENCE	MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE KVQSRFVVSLAYAYE				FRAGMENT	NO
FUNCTION	Specifically phosphorylates the activated forms of Gs protein-coupled receptors

Interacting with G-proteins:
Family:Gq/11		REFERENCES:	15251227 \| 14654303
1	GPR0029	Galpha-11-Homo sapiens


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	University of Athens Faculty of Biology Dept. of Cell Biology and Biophysics	Biophysics & Bioinformatics Laboratory