|gpDB: a database of G-proteins and their interaction with GPCRs|
|Introduction||Navigation||Text Search||Blast Search||Pattern Search||User Manual|
|GpDB is a publicly accessible, relational database of G-proteins and their interactions with GPCRs and effector molecules. The sequences are classified according to a hierarchy of different classes, families and sub-families, based on extensive literature search. The main innovation besides the classification of both G-proteins and GPCRs is the relational model of the database, describing the known coupling specificity of the GPCRs to their respective alpha subunit of G-proteins and also the interaction between G-protein subfamilies and specific effector types, a unique feature not available in any other database. There is full sequence information with cross-references to publicly available databases, and the user may submit advanced queries for text search. Furthermore there is an interface for running BLAST against the database and a pattern search tool. The database will be very useful for the study of G-protein/GPCR and G-protein/effector interactions and for future development of algorithms predicting this interaction.||
G-proteins: 391 entries
GPCRs: 2738 entries
Effectors: 1390 entries
last update: 20/03/2008
Margarita C Theodoropoulou, Pantelis G Bagos, Ioannis C Spyropoulos and Stavros J Hamodrakas.
|"gpDB: A database of GPCRs, G-proteins, Effectors and their interactions."|
|Bioinformatics. 2008 Jun 15;24(12):1471-2.||
Elefsinioti AL, Bagos PG, Spyropoulos IC, Hamodrakas SJ.
"A database for G proteins and their interaction with GPCRs."
BMC Bioinformatics. 2004 5:208.
|Linking to gpDB:|
|Example for GPCR GPCR0060:||http://bioinformatics.biol.uoa.gr/gpDB/gpcrview.jsp?id=60|
|Example for G-protein GPR0060:||http://bioinformatics.biol.uoa.gr/gpDB/gprotview.jsp?id=60|
|Example for Effector EFF0060:||http://bioinformatics.biol.uoa.gr/gpDB/effectorview.jsp?id=60|
|Designed for viewing with Internet Explorer 4 or above, Netscape 6 or above.|
|contact biodbbiol.uoa.gr for comments, corrections and data (sequence) submission.|
University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics