gpDB: a database of G-proteins and their interaction with GPCRs

GpDB is a publicly accessible, relational database of G-proteins and their interactions with GPCRs and effector molecules. The sequences are classified according to a hierarchy of different classes, families and sub-families, based on extensive literature search. The main innovation besides the classification of both G-proteins and GPCRs is the relational model of the database, describing the known coupling specificity of the GPCRs to their respective alpha subunit of G-proteins and also the interaction between G-protein subfamilies and specific effector types, a unique feature not available in any other database. There is full sequence information with cross-references to publicly available databases, and the user may submit advanced queries for text search. Furthermore there is an interface for running BLAST against the database and a pattern search tool. The database will be very useful for the study of G-protein/GPCR and G-protein/effector interactions and for future development of algorithms predicting this interaction.	Statistics: G-proteins: 391 entries GPCRs: 2738 entries Effectors: 1390 entries Species: 469 last update: 20/03/2008
Margarita C Theodoropoulou, Pantelis G Bagos, Ioannis C Spyropoulos and Stavros J Hamodrakas.
"gpDB: A database of GPCRs, G-proteins, Effectors and their interactions."
Bioinformatics. 2008 Jun 15;24(12):1471-2.
Elefsinioti AL, Bagos PG, Spyropoulos IC, Hamodrakas SJ.
"A database for G proteins and their interaction with GPCRs."
BMC Bioinformatics. 2004 5:208.

Linking to gpDB:
Example for GPCR GPCR0060:	http://bioinformatics.biol.uoa.gr/gpDB/gpcrview.jsp?id=60
Example for G-protein GPR0060:	http://bioinformatics.biol.uoa.gr/gpDB/gprotview.jsp?id=60
Example for Effector EFF0060:	http://bioinformatics.biol.uoa.gr/gpDB/effectorview.jsp?id=60


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	University of Athens Faculty of Biology Dept. of Cell Biology and Biophysics	Biophysics & Bioinformatics Laboratory